Prof Dr.
Tilman Grune

vita//cv
forschung//research
projekte//projects
publikationen//publications

kontakt//contact
impressum//imprint
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Originalartikel//Original Articles

2000

• Mehlhase J, Gieche J, Ullrich O, Sitte N, Grune T. LPS-induced protein oxidation and proteolysis in BV-2 microglial cells. IUBMB Life. 2000; 50:331-5.
• Shringarpure R, Grune T, Sitte N, Davies KJ. 4-Hydroxynonenal-modified amyloid-beta peptide inhibits the proteasome: possible importance in Alzheimer's disease. Cell Mol Life Sci. 2000; 57:1802-9.
• Sitte N, Merker K, Von Zglinicki T, Davies KJ, Grune T. Protein oxidation and degradation during cellular senescence of human BJ fibroblasts: part II--aging of nondividing cells. FASEB J. 2000; 14:2503-10.
• Sitte N, Merker K, Von Zglinicki T, Grune T, Davies KJ. Protein oxidation and degradation during cellular senescence of human BJ fibroblasts: part I--effects of proliferative senescence.
  FASEB J. 2000; 14:2495-502.
• Sitte N, Huber M, Grune T, Ladhoff A, Doecke WD, Von Zglinicki T, Davies KJ. Proteasome inhibition by lipofuscin/ceroid during postmitotic aging of fibroblasts. FASEB J. 2000; 14:1490-8.
• Serra V, Grune T, Sitte N, Saretzki G, von Zglinicki T. Telomere length as a marker of oxidative stress in primary human fibroblast cultures. Ann N Y Acad Sci. 2000; 908:327-30.
• Rudeck M, Volk T, Sitte N, Grune T. Ferritin oxidation in vitro: implication of iron release and degradation by the 20S proteasome. IUBMB Life. 2000; 49:451-6.
• Reinheckel T, Ullrich O, Sitte N, Grune T. Differential impairment of 20S and 26S proteasome activities in human hematopoietic K562 cells during oxidative stress. Arch Biochem Biophys. 2000; 377:65-8.
• Sitte N, Merker K, von Zglinicki T, Grune T. Protein oxidation and degradation during proliferative senescence of human MRC-5 fibroblasts. Free Radic Biol Med. 2000; 28:701-8.
• Ludat K, Sommerburg O, Grune T, Siems WG, Riedel E, Hampl H. Oxidation parameters in complete correction of renal anemia. Clin Nephrol. 2000; 53:S30-5.
• Sommerburg O, Grune T, Hampl H, Riedel E, Ehrich JH, Siems WG. Does treatment of renal anemia with recombinant erythropoietin influence oxidative stress in hemodialysis patients? Clin Nephrol. 2000; 53:S23-9.
• Merker K, Sitte N, Grune T. Hydrogen peroxide-mediated protein oxidation in young and old human MRC-5 fibroblasts. Arch Biochem Biophys. 2000; 375:50-4.
• Göhler L, Hahnemann T, Michael N, Oehme P, Steglich HD, Conradi E, Grune T, Siems WG. Reduction of plasma catecholamines in humans during clinically controlled severe underfeeding. Prev Med. 2000; 30:95-102.

1999

• Sommerburg, Sostmann K, Grune T, Ehrich JH. Oxidative stress in hemodialysis patients treated with a dialysis membrane which has alpha-tocopherol bonded to its surface. Biofactors. 1999; 10:121-4.
• Pantke U, Volk T, Schmutzler M, Kox WJ, Sitte N, Grune T. Oxidized proteins as a marker of oxidative stress during coronary heart surgery. Free Radic Biol Med. 1999; 27:1080-6.
• Ullrich O, Reinheckel T, Sitte N, Grune T. Degradation of hypochlorite-damaged glucose-6-phosphate dehydrogenase by the 20S proteasome. Free Radic Biol Med. 1999; 27:487-92.
• Lehmann C, Egerer K, Georgiew A, Weber M, Grune T, Kox WJ. Inhibition of tumor necrosis factor-alpha release in rat experimental endotoxemia by treatment with the 21-aminosteroid U-74389G. Crit Care Med. 1999; 27:1164-7.
• Siems WG, Brenke R, Sommerburg O, Grune T. Improved antioxidative protection in winter swimmers. QJM. 1999; 92:193-8.
• Ludat K, Sommerburg O, Grune T, Siems WG, Riedel E, Hampl H. Oxidationsparameter bei vollständiger Korrektur der renalen Anämie. Nieren- und Hochdruckkrankheiten Suppl. 1999; 01:S38-S44
• Mayer-Kuckuk P, Ullrich O, Ziegler M, Grune T, Schweiger M. Functional interaction of poly(ADP-ribose) with the 20S proteasome in vitro. Biochem Biophys Res Commun. 1999; 259:576-81.
• Luther B, Lehmann C, Grune T, Meyer R, Schwenke G, Beutel H, Bürger K. Controlled reperfusion of ischemic extremity musculature to prevent free radical induced lesions. Zentralbl Chir. 1999; 124:336-43.
• Ullrich O, Reinheckel T, Sitte N, Hass R, Grune T, Davies KJ. Poly-ADP ribose polymerase activates nuclear proteasome to degrade oxidatively damaged histones. Proc Natl Acad Sci U S A. 1999; 96:6223-8.
• Ullrich O, Sitte N, Sommerburg O, Sandig V, Davies KJ, Grune T. Influence of DNA binding on the degradation of oxidized histones by the 20S proteasome. Arch Biochem Biophys. 1999; 362:211-6.
• Petras T, Siems W, Henke W, Jung K, Olbricht CJ, Gwinner W, Grune T. Metabolic rates of 4-hydroxynonenal in tubular and mesangial cells of the kidney. Exp Nephrol. 1999; 7:59-62.

1998

• Sitte N, Merker K, Grune T. Proteasome-dependent degradation of oxidized proteins in MRC-5 fibroblasts. FEBS Lett. 1998; 440:399-402.
• Reinheckel T, Sitte N, Ullrich O, Kuckelkorn U, Davies KJ, Grune T. Comparative resistance of the 20S and 26S proteasome to oxidative stress. Biochem J. 1998; 335:637-42.
• Sommerburg O, Grune T, Hampl H, Riedel E, van Kuijk FJ, Ehrich JH, Siems WG. Does long-term treatment of renal anaemia with recombinant erythropoietin influence oxidative stress in haemodialysed patients? Nephrol Dial Transplant. 1998; 13:2583-7.
• Mertsch K, Grune T, Kunstmann S, Wiesner B, Ladhoff AM, Siems WG, Haseloff RF, Blasig IE. Protective effects of the thiophosphate amifostine (WR 2721) and a lazaroid (U83836E) on lipid peroxidation in endothelial cells during hypoxia/reoxygenation. Biochem Pharmacol. 1998; 56:945-54.
• Sommerburg O, Ullrich O, Sitte N, von Zglinicki D, Siems W, Grune T. Dose- and wavelength-dependent oxidation of crystallins by UV light--selective recognition and degradation by the 20S proteasome. Free Radic Biol Med. 1998; 24:1369-74.
• Grune T, Blasig IE, Sitte N, Roloff B, Haseloff R, Davies KJ. Peroxynitrite increases the degradation of aconitase and other cellular proteins by proteasome. J Biol Chem. 1998; 273:10857-62.
• Siems WG, Pimenov AM, Esterbauer H, Grune T. Metabolism of 4-hydroxynonenal, a cytotoxic lipid peroxidation product, in thymocytes as an effective secondary antioxidative defense mechanism. J Biochem. 1998; 123:534-9.
• Siems WG, Grune T. High capacity of secondary antioxidative pathways in thymocytes: rapid detoxification of 4-hydroxynonenal. Internat. J. Thymology 1998; 6:518-529.
• Lehmann C, Weber M, Krausch D, Wauer H, Newie T, Rohr U, Hensel M, Glatzel E, Priem F, Grune T, Kox WJ. Parenteral selenium supplementation in critically ill patients--effects on antioxidant metabolism. Z Ernahrungswiss. 1998; 37:106-9.

1997

• Haberland A, Henke W, Grune T, Siems W, Jung K, Schimke I. Differential response of oxygen radical metabolism in rat heart, liver and kidney to cyclosporine A treatment. Inflamm Res. 1997; 46:452-4.
• Siems WG, Capuozzo E, Verginelli D, Salerno C, Crifò C, Grune T. Inhibition of NADPH oxidase-mediated superoxide radical formation in PMA-stimulated human neutrophils by 4-hydroxynonenal--binding to -SH and -NH2 groups. Free Radic Res. 1997; 27:353-8.
• Ullrich O, Grune T. Detection of 8-hydroxydeoxyguanosine in K562 human hematopoietic cells by high-performance capillary electrophoresis. J Chromatogr B Biomed Sci Appl. 1997; 697:243-9.
• Brenke R, Siems W, Grune T. Therapieoptimierungsmaßnahmen beim chronischen Lymphödem. Lymphologie 1997; 21:20-22.
• Grune T, Siems WG, Petras T. Identification of metabolic pathways of the lipid peroxidation product 4-hydroxynonenal in in situ perfused rat kidney. J Lipid Res. 1997; 38:1660-5.
• Schwendel A, Grune T, Holzhütter HG, Siems WG. Models for the regulation of purine metabolism in rat hepatocytes: evaluation of tracer kinetic experiments. Am J Physiol. 1997; 273:G239-46.
• Michel P, Eggert W, Albrecht-Nebe H, Grune T. Increased lipid peroxidation in children with autoimmune diseases. Acta Paediatr. 1997; 86:609-12.
• Siems WG, Zollner H, Grune T, Esterbauer H. Metabolic fate of 4-hydroxynonenal in hepatocytes: 1,4-dihydroxynonene is not the main product. J Lipid Res. 1997; 38:612-22.
• Grune T, Müller K, Zöllner S, Haseloff R, Blasig IE, David H, Siems W. Evaluation of purine nucleotide loss, lipid peroxidation and ultrastructural alterations in post-hypoxic hepatocytes. J Physiol. 1997; 498:511-22.
• Grune T, Michel P, Sitte N, Eggert W, Albrecht-Nebe H, Esterbauer H, Siems WG. Increased levels of 4-hydroxynonenal modified proteins in plasma of children with autoimmune diseases. Free Radic Biol Med. 1997; 23:357-60.
• Ullrich O, Huser H, Ehrlich W, Grune T. Intracellular metabolism of 4-hydroxynonenal in primary cultures of rabbit synovial fibroblasts. Free Radic Biol Med. 1997; 22:1153-7.

1996

• Kunstmann S, Mertsch K, Blasig IE, Grune T. High metabolic rates of 4-hydroxynonenal in brain capillary endothelial cells during hypoxia/reoxygenation. Brain Res. 1996; 740:353-5.
• Schmidt H, Grune T, Müller R, Siems WG, Wauer RR. Increased levels of lipid peroxidation products malondialdehyde and 4-hydroxynonenal after perinatal hypoxia. Pediatr Res. 1996; 40:15-20.
• Müller O, Gruner S, Grune T, Siems W. Bildung zytotoxischer Lipidperoxidationsprodukte durch UV-B Bestrahlung im Tiermodell. J. Dermatol. 1996; 182:176-78.
• Sommerburg O, Brenke A., Müller GM, Siems W, Grune T. Beschleunigte Lipidperoxidation bei der systemischen Sklerodermie. Zeitschrift für Dermatologie 1996; 182:124-28
• Grune T, Reinheckel T, Davies KJ. Degradation of oxidized proteins in K562 human hematopoietic cells by proteasome. J Biol Chem. 1996; 271:15504-9.
• Schwarzer E, Müller O, Arese P, Siems WG, Grune T. Increased levels of 4-hydroxynonenal in human monocytes fed with malarial pigment hemozoin. A possible clue for hemozoin toxicity. FEBS Lett. 1996; 388:119-22.
• Grune T, Scherat T, Behrend H, Conradi E, Brenke R, Siems W. Influence of Allium sativum Linné on oxidative stress status - a clinical investigation. Phytomedicine 1996; 2:205-07.
• Ullrich O, Henke W, Grune T, Siems WG. The effect of the lipid peroxidation product 4-hydroxynonenal and of its metabolite 4-hydroxynonenoic acid on respiration of rat kidney cortex mitochondria. Free Radic Res. 1996; 24:421-7.
• Ullrich O, Siems WG, Lehmann K, Huser H, Ehrlich W, Grune T. Inhibition of poly(ADP-ribose) formation by 4-hydroxynonenal in primary cultures of rabbit synovial fibroblasts. Biochem J. 1996; 315:705-8.

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