Prof Dr.
Tilman Grune

vita//cv
forschung//research
projekte//projects
publikationen//publications

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impressum//imprint
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Originalartikel//Original Articless

1995

• Petras T, Siems WG, Grune T. 4-hydroxynonenal is degraded to mercapturic acid conjugate in rat kidney. Free Radic Biol Med. 1995; 19:685-8.
• Lehmann C, Luther B, Holzäpfel A, Roth S, David H, Grune T, Siems W, Bürger K, Kox WJ. Perioperative vascular flushing perfusion in acute mesenteric artery occlusion. Eur J Vasc Endovasc Surg. 1995; 10:265-71.
• Blasig IE, Grune T, Schönheit K, Rohde E, Jakstadt M, Haseloff RF, Siems WG. 4-Hydroxynonenal, a novel indicator of lipid peroxidation for reperfusion injury of the myocardium. Am J Physiol. 1995; 269:H14-22.
• Mertsch K, Grune T, Siems WG, Ladhoff A, Saupe N, Blasig IE. Hypoxia and reoxygenation of brain endothelial cells in vitro: a comparison of biochemical and morphological response. Cell Mol Biol (Noisy-le-grand). 1995; 41:243-53.
• Grune T, Reinheckel T, Joshi M, Davies KJ. Proteolysis in cultured liver epithelial cells during oxidative stress. Role of the multicatalytic proteinase complex, proteasome. J Biol Chem. 1995; 270:2344-51.
• Schmidt H, Siems WG, Grune T, Grauel EL. Concentration of purine compounds in the cerebrospinal fluid of infants suffering from sepsis, convulsions and hydrocephalus. J Perinat Med. 1995; 23:167-74.
• Grune T, Sommerburg O, Petras T, Siems WG. Postanoxic formation of aldehydic lipid peroxidation products in human renal tubular cells. Free Radic Biol Med. 1995; 18:21-7.
• Siems WG, Grune T, Esterbauer H. 4-Hydroxynonenal formation during ischemia and reperfusion of rat small intestine. Life Sci. 1995; 57:785-9.

1994

• Blasig IE, Mertsch K, Ladhoff A, Grune T. Lipid peroxidation and lipofuscin granula in brain endothelial cell cultures during reoxygenation. Ann N Y Acad Sci. 1994; 738:374-7.
• Grune T, Siems WG, Zollner H, Esterbauer H. Metabolism of 4-hydroxynonenal, a cytotoxic lipid peroxidation product, in Ehrlich mouse ascites cells at different proliferation stages. Cancer Res. 1994; 54:5231-5.
• Schwendel A, Siems WG, Grune T, Holzhütter HG. Transitions of hepatic purine metabolism of Ehrlich ascites tumor bearing mice in different phases of tumor growth. Biochem Mol Biol Int. 1994; 34:457-63.
• Ullrich O, Grune T, Henke W, Esterbauer H, Siems WG. Identification of metabolic pathways of the lipid peroxidation product 4-hydroxynonenal by mitochondria isolated from rat kidney cortex. FEBS Lett. 1994; 352:84-6.
• Lehmann C, Luther B, Holzäpfel A, Roth S, David H, Grune T, Siems W, Kox WJ. Reduktion von intestinalen Ischämieschäden durch Oxypurinol. Der Anästhesist 1994; 12: 819.
• Lehmann C, Luther B, Grune T, Siems W, David H, Kox WJ. Effektivität von Oxipurinol zur Reduktion von Ischämieschäden an Intestinum und Niere bei Aortenaneurismaoperationen. Zentralbl. Chir. 1994; 119Supl1; 38-40.
• Fuchs J, Schofer H, Ochsendorf F, Janka S, Milbradt R, Buhl R, Unkelbach U, Freisleben HJ, Oster O, Siems W, Grune T, Esterbauer H. Antioxidants and peroxidation products in the blood of HIV-1 infected patients with HIV-associated skin diseases. Eur. J. Dermatol. 1994; 4:148-53.
• Siems WG, Brenke R, Beier A, Grünberger P, Grune T, Krämer K, Conradi E, Schrauzer GN. Therapieoptimierung beim chronischen Lymphödem chirurgisch behandelter Tumorpatienten durch Natriumselenit. Dt. Z. Onkologie/ J. Onkology 1984; 26:128-32.
• Beier A, Siems W, Brenke R, Grune T. Increased formation of free radicals in chronic lymphedema. Z Lymphol. 1994; 18:8-11.
• Grune T, Schönheit K, Blasig I, Siems W. Reduced 4-hydroxynonenal degradation in hearts of spontaneously hypertensive rats during normoxia and postischemic reperfusion. Cell Biochem Funct. 1994; 12:143-7.
• Siems WG, Schwendel A, Grune T, Holzhütter HG, Uhlig R. Estimation of metabolic flux rates in liver purine catabolism of tumour-bearing mice by computer simulation of radioactive tracer experiments. Cell Biochem Funct. 1994; 12:1-9.
• Grune T, Siems WG, Kowalewski J, Esterbauer H. Postischemic accumulation of the lipid peroxidation product 4-hydroxynonenal in rat small intestine. Life Sci. 1994; 55:693-9. Erratum in: Life Sci 1994; 56:61.

1993

• Fuchs J, Schöfer H, Milbradt R, Freisleben HJ, Buhl R, Siems W, Grune T. Studies on lipoate effects on blood redox state in human immunodeficiency virus infected patients. Arzneimittelforschung. 1993; 43:1359-62.
• Siems WG, Grune T, Schmidt H, Tikhonov YV, Pimenov AM. Purine nucleotide levels in host tissues of Ehrlich ascites tumor-bearing mice in different growth phases of the tumor. Cancer Res. 1993; 53:5143-7.
• Müller K, Grune T, Klee S, Jochmann C, Ungemach F, Siems W. Trichlorobromomethane-induced changes of purine nucleotides in hepatocytes. Biochem Mol Biol Int. 1993; 31:405-12.
• Holzhütter HG, Schwendel A, Grune T, Quedenau J, Siems W. Estimation of steady-state flux rates in metabolic systems by computer simulations of radioactive tracer experiments. Comput Appl Biosci. 1993; 9:573-80.
• Grune T, Schneider W, Siems WG. Reoxygenation injury of rat hepatocytes: evaluation of nucleotide depletion and oxidative stress as causal components. Cell Mol Biol (Noisy-le-grand). 1993; 39:635-50.
• Grune T, Siems WG, Schneider W. Accumulation of aldehydic lipid peroxidation products during postanoxic reoxygenation of isolated rat hepatocytes. Free Radic Biol Med. 1993; 15:125-32.
• Matthes G, Strunk S, Siems W, Grune T. Posttransfusional changes of 2,3-diphosphoglycerate and nucleotides in CPD-SAGM-preserved erythrocytes. Infusionsther Transfusionsmed. 1993; 20:89-92.
• Grune T, Ross GA, Schmidt H, Siems W, Perrett D. Optimized separation of purine bases and nucleosides in human cord plasma by capillary zone electrophoresis. J Chromatogr. 1993; 636:105-11.
• Sommerburg O, Grune T, Klee S, Ungemach FR, Siems WG. Formation of 4-hydroxynonenal and further aldehydic mediators of inflammation during bromotrichlorornethane treatment of rat liver cells. Mediators Inflamm. 1993; 2:27-31.
• Grune T, Siems WG, Schönheit K, Blasig IE. Release of 4-hydroxynonenal, an aldehydic mediator of inflammation, during postischaemic reperfusion of the myocardium. Int J Tissue React. 1993; 15:145-50.

1992

• Müller K, Siems WG, Grune T, David H, Henke W, Jung K. Adaptational increase of liver glutathione content during long-term application of cyclosporine A may attenuate toxic side effects. Cell Mol Biol (Noisy-le-grand). 1992; 38:729-38.
• Siems W, Grune T, Hampl H, Wendel G, Gerber G, Riedel E. Changed purine nucleotide concentrations and enzyme activities in erythrocytes of haemodialysis patients undergoing erythropoietin therapy. Eur J Clin Chem Clin Biochem. 1992; 30:455-60.
• Siems WG, Zollner H, Grune T, Esterbauer H. Qualitative and quantitative determination of metabolites of the lipid peroxidation product 4-hydroxynonenal from hepatocytes, enterocytes and tumor cells. Fresenius' J. Anal. Chem. 1992; 343:75-76.
• Schmidt H, Siems WG, Grune T, Grauel EL. Purine compounds in cerebrospinal fluid of infants with cerebral convulsions and hydrocephalus. Wiss. Zeitschrift der Humboldt-Univ. zu Berlin, R. Medizin 1992; 41:125-28.
• Grune T, Siems W, Esterbauer H. Comparison of different assays for malondialdehyde using thiobarbituric acid. Fresenius' J. Anal. Chem. 1992; 343:135.
• Siems WG, Grune T, Werner A, Gerber G, Buntrock P, Schneider W. Protective influence of oxypurinol on the trinitrobenzene sulfonic acid(TNB) model of inflammatory bowel disease in rats. Cell Mol Biol. 1992; 38:189-99.
• Pompella A, Comporti M, Müller K, Grune T, Siems W. Confocal laser scanning fluorescence microscopy of DABCSH-labeled protein carbonyls in isolated cells. Applied Fluorescence Technology 1992; 4:8-11.
• Grune T, Siems W, Uhlig R, Jakstadt M. Adenine metabolism of Ehrlich mouse ascites cells in proliferating and resting phase of tumor growth. Biochem Int. 1992; 26:199-209.

1991

• Grune T, Siems W, Kowalewski J, Zollner H, Esterbauer H. Identification of metabolic pathways of the lipid peroxidation product 4-hydroxynonenal by enterocytes of rat small intestine. Biochem Int. 1991; 25:963-71.
• Siems W, Grune T, Lehmann C, Gemkow O, Ansorge K, Luther B, Gerber G. Superoxide dismutase promotes ATP and GTP restoration of rat small intestine during postischaemic reperfusion. Pharmazie. 1991; 46:735-7.
• Kowalewski J, Siems W, Grune T, Werner A, Esterbauer H, Gerber G. Nukleotidabbau und Sauerstoffradikalbildung bei Ischämie und Reperfusion des Rattendünndarms. Zeitschrift für Klinische Medizin 1991; 46:143-46.
• David H, Siems W, Kowalewski J, Grune T, Bimmler M. Ultrastrukturell-funktionelle Veränderungen der Dünndarmmukosa bei Ischämie und Reperfusion. Zeitschrift für Klinische Medizin 1991; 46:609-16.
Grune T, Siems WG, Kowalewski J, Gerber G, David H, Esterbauer H. Involvement of lipid peroxidation in the reperfusion injury of small intestine of rats - formation of the lipid peroxidation product 4-hydroxynonenal. Wiss. Zeitschrift der Humboldt-Univ. zu Berlin, R. Medizin 1991; 40:29-35.
• Siems W, Grune T, Schneider W, Gerber G. Oxidative stress and nucleotide degradation in isolated hepatocytes during anoxia and reoxigenation in presence of oxipurinol. Wiss. Zeitschrift der Humboldt-Univ. zu Berlin, R. Medizin 1991; 40:21-28.
• Grune T, Siems WG, Gerber G, Uhlig R. Determination of the ultraviolet absorbance and radioactivity of purine compounds separated by high-performance liquid chromatography. Application to metabolic flux rate analysis. J Chromatogr. 1991; 553:193-9.
• Grune T, Siems W, Gerber G, Tikhonov YV, Pimenov AM, Toguzov RT. Changes of nucleotide patterns in liver, muscle and blood during the growth of Ehrlich ascites cells: application of the reversed-phase and ion-pair reversed-phase high-performance liquid chromatography with radial compression column. J Chromatogr. 1991; 563:53-61.
• Siems W, Kowalewski J, David H, Grune T, Bimmler M. Discrepancy between biochemical normalization and morphological recovery of jejunal mucosa during postischemic reperfusion in presence of the xanthine oxidase inhibitor oxypurinol. Cell Mol Biol. 1991; 37:213-26.

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